Enhanced secretion of biologically active murine interleukin-12 by Lactococcus lactis.

نویسندگان

  • Antonio Fernandez
  • Nikki Horn
  • Udo Wegmann
  • Claudio Nicoletti
  • Michael J Gasson
  • Arjan Narbad
چکیده

The novel signal peptide SLPmod was used for the secretion of murine interleukin-12 (mIL-12) by Lactococcus lactis. A >4-fold increase in secretion was observed when SLPmod was used instead of the Usp45-derived secretion signal. Oral delivery of this cytokine using the autoinducible host L. lactis FI5876 utilizing SLPmod resulted in a significant increase in mIL-12 plasma levels in mice.

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عنوان ژورنال:
  • Applied and environmental microbiology

دوره 75 3  شماره 

صفحات  -

تاریخ انتشار 2009